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DONA® contains the original crystalline glucosamine sulfate shown effective in clinical trials. In two 3-year clinical studies crystalline glucosamine sulfate was shown effective to help maintain the normal function of cartilage and to support healthy joint function.* DONA crystalline glucosamine sulfate is sold around the world in more than 60 countries. Take two caplets together daily with water or juice. Use only as directed. Glucosamine is derived from shrimp and crab; if you are allergic to shellfish, please consult your doctor before taking. Please consult your physician bfore taking if you are pregnant or breast-feeding.